Monday, December 20, 2010


Why 9? The number nine has long been used as a superlative. Classical mythology gave us the Nine Muses of Arts and Learning. The Nine Worthies were characters drawn from the Pagan and Jewish history and from the Bible. This distinguished group consisted of Hector, Alexander, Julius Caesar, Joshua, David, Judas Maccabaeus, King Arthur, Charlemagne, and Godfrey of Bouillon. This then is a takeoff of the main constituent, Arginine, the 9 chaperone ingredients and it is exceptional for total body health.

In 1998, the Nobel Prize was awarded to Louis Ignarro for the discovery of EDRF(endothelium-derived relaxing factor), a chemical produced in the lining of the blood vessels, which keeps them healthy. Several years earlier, Stanford's Dr. John Cooke and other investigators had found that specific nutrients enhance EDRF production and improve blood flow in people with high cholesterol, high blood pressure, diabetes, or other risk factors for heart disease. 
The atom of cardiovascular health--a tiny molecule called Nitric Oxide. NO, as it is known by chemists, is the signaling molecule produced by the body, and is a vasodilator that helps control blood flow to every part of the body. Dr. Ignarro's findings led to the development of Viagra and other patented and supplemental products such as Pro-Argi 9.

Arginine, or more correctly L-Arginine is the natural molecule in our body that produces NO in that one-cell-thick lining of our blood vessels called the endothelium. NO has a beneficial effect on the whole cardiovascular system. It relaxes and enlarges the blood vessels, prevents blood clots that can trigger strokes and heart attacks, regulates blood pressure and the accumulation of plaque in the blood vessels. Current research indicates that NO may help lower cholesterol by facilitating the actions of statin drugs like Lipitor or lower lipids by itself. It also has been shown to improve the immune system, facilitate healing, prevent cancer, enhance nerve and brain function and act as an antiaging molecule by stimulating HGH (Human Growth Hormone). It is also the promolecule of Argmantine which decreases pain and promotes better cognitive health which is a subject of a whole discussion that will be forthcoming.

Arginine is a conditionally nonessential amino acid, meaning in healthy young folks it can be manufactured by the human body, and does not need to be obtained directly through the diet. But in older people or those with other diseases including stress, the biosynthetic pathway does not produce sufficient amounts, and must be consumed through diet. Arginine is found in a wide variety of foods, including red meat and dairy products. However, these need to be consumed in large quantities such as two pounds of steak or three quarts of milk daily. This so called “food” is inflammatory and causes poor health in the majority of 21st centurions.

In our body, Arginine is synthesized from another semi-essential amino acid, citrulline, by several cellular enzymes. But it is a very energy costly, with each molecule produced two ATP equivalents are used up. In healthy humans, synthesis of arginine occurs principally in the intestine and kidney. The lining of the small intestine produces citrulline primarily from glutamine which naturally is in our diet if we eat healthily. The kidney extracts citrulline from the circulation and converts it to arginine, which is returned to the circulation. Consequently, poor diet, impairment of small bowel or kidney function can reduce arginine and NO. To make matters worse there is a competing molecule that some of us have in our body, ADMA, that causes an even lower level of NO and health. More about ADMA later.

Since the early 1970’s L-Arginine has been used as a supplement with only placebo effect, but in the last five years there have been several good products available. Engineered by Dr Ignarro himself are Niteworks and most recently Pro-Argi 9. These have at least 4 grams of L-Arginine. 200mg of L-citrullene , and chaperone molecules such as Vitamin C, Folic Acid, and Alpha Lipoic Acid. It comes in a canister or packets of powdered product. One scoop or packet is taken at least 90 minutes after eating and immediately before sleep. Carbohydrates and protein inhibit its intestinal absorption and taken at bedtime stimulates HGH release as well as insuring a good nights sleep. Certainly one could double and even triple the dose for better and quicker health benefit, but it is not necessary.

Pro Argi 9 is available from certain clinicians in the Tulsa area and on line. When a clinician or a patient feels that this product is needed, a special test called a Pulse Max to be described later is preformed. Most clinicians charge $50 for the study, but in most cases is paid for by insurances. This details the health of the cardiovascular system. The study is repeated three months later and if there is not considerable improvement in the test and how the individuals feels, the price of the product is returned by the organization that markets it. The cost is about $ 180 for three months and well worth it. For further information, call or ask at our front desk.

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